GenomeMET
The GenomeMET project, funded under the European Partnership on Metrology (METPART), aims to improve the accuracy and comparability of genomic profiling across the European Healthcare System to support cancer diagnosis and tailored treatment strategies.
About the project
Genomic profiling techniques such as Next Generation Sequencing (NGS) are used to obtain information about an individual’s genetic profile. This information can then be used to develop personalised treatment and aid earlier and more accurate diagnosis and monitoring of diseases such as cancer.
However, the analytical complexity of genomic profiling introduces significant uncertainties, which can impact on the reliability and accuracy of the testing. Metrology (measurement science) is fundamental to provide confidence in data to overcome these challenges and support implementation of genomic profiling.
The GenomeMET project, funded under the European Partnership on Metrology (METPART), aims to improve the accuracy and comparability of genomic profiling across the European Healthcare System. This collaborative project is focused on developing a robust metrological (measurement) infrastructure to support method validation and quality control at both the pre-analytical and analytical stages. The project will also develop reference measurement procedures for measuring genomic biomarkers.
The outcomes of the GenomeMET project will support earlier and more accurate cancer diagnostics, alongside tailored treatment strategies.
The consortium
- Instituto Nazionale Di Ricerca Metrologica (INRIM – the National Measurement Institute of Italy)- Project lead
- NML at LGC
- LNE
- METAS
- MHRA
- NIB
- PTB
- UME
- instrument manufacturers
- EQA scheme providers
- regulatory bodies
- sequencing centres
- clinical laboratories
Work package 1
The NML is leader of Work Package (WP) 1 of the project. WP1 focuses on establishing a metrology framework essential for the quality assurance (QA) and quality control (QC) implementation in clinical laboratory settings, particularly for Next Generation Sequencing (NGS) workflows.
The work package aims to create a comprehensive metrology framework that not only enhances the reliability and traceability of genomic data but also aligns with international standards and regulations. By doing so, it seeks to pave the way for improved diagnostic precision, fostering advancements in personalised medicine and patient care.
Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or EURAMET. Neither the European Union nor the granting authority can be held responsible for them.
The project has received funding from the European Partnership on Metrology, co-financed from the European Union’s Horizon Europe Research and Innovation Programme and by the Participating States.
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If you’re interested in exploring partnership opportunities with the NML or learning more about our measurement capabilities, we’d love to hear from you.